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A predictive test of the risk of Alzheimer's

Middle-aged women in high blood levels of homocysteine are predictive of the likelihood of incurring double, advanced age, illness.

In middle-aged women, high levels of a specific amino acid are predictive of a doubling of the probability of encountering old age in Alzheimer's disease: what is clear from research conducted at the Sahlgrenska Academy of Göteborg University, Sweden. The discovery could lead to the development of a simple test to determine, long before they have any symptoms, the risk of incurring the disease.

The study was based on a prospective epidemiological survey on women in Gothenburg, which began in the sixties, has followed the health ofabout 1500 women aged between 38 and 60 years ,also providing for the regular collection and subsequent analysis blood samples.

The study compared the results of this analysis with information on current clinical status of the subjects followed. "Alzheimer's disease is twice as common among women who had the highest values of homocysteine than those who had the lowest values and the risk of developing any type of dementia is higher by 70 percent, " said Dimitri Zylberstein, who led the study.

Homocysteine is an amino acid important for the metabolism of the body, but when that is present at excessive levels can increase the risk of blood clots.

The researchers point out, however, that the investigation can not be inferred if the omocistena may be a contributory cause of the disease or whether there is an underlying factor that determines both the increase of its levels and dementia.